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4585 matches
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organism
protein
1)
Homo sapiens
DIS3 - Exosome complex
exonuclease
RRP44; Putative catalytic component of the
RNA
exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular
RNA
processing
and degradation events. In the nucleus, the
RNA
exosome complex is involved in proper maturation of stable
RNA
species such as rRNA, snRNA and snoRNA, in the elimination of
RNA
processing
by-products and non-coding 'pervasive' transcripts, such as antisense
RNA
species and promoter-upstream transcripts (PROMPTs), and of mRNAs with
processing
defects, thereby limiting or excluding their export to t [...]
[a.k.a. R-HSA-450604, ENST00000377767, ENST00000327297]
2)
Homo sapiens
DIS3L - DIS3-like
exonuclease
1; Putative cytoplasm-specific catalytic component of the
RNA
exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular
RNA
processing
and degradation events. In the cytoplasm, the
RNA
exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in
RNA
surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
[a.k.a. DIS3L-208, NP_001310868.1, OMIM:614183]
3)
Homo sapiens
MGME1 - Mitochondrial genome maintenance
exonuclease
1; Metal-dependent single-stranded DNA (ssDNA)
exonuclease
involved in mitochondrial genome maintenance. Has preference for 5'-3'
exonuclease
activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the
processing
of displaced DNA containing Okazaki fragments during
RNA
- primed DNA synthesis on the lagging strand or via
processing
of DNA flaps during long-patch base excision repair. Specifically binds 5- h [...]
[a.k.a. XP_006723726.1, AK315532, AL121585]
4)
Mus musculus
Dis3 - Exosome complex
exonuclease
RRP44; Putative catalytic component of the
RNA
exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular
RNA
processing
and degradation events. In the nucleus, the
RNA
exosome complex is involved in proper maturation of stable
RNA
species such as rRNA, snRNA and snoRNA, in the elimination of
RNA
processing
by-products and non-coding 'pervasive' transcripts, such as antisense
RNA
species and promoter-upstream transcripts (PROMPTs), and of mRNAs with
processing
defects, thereby limiting or excluding their export to t [...]
[a.k.a. R-MMU-450513, Protein DIS3 homolog, NM_001360051.1]
5)
Mus musculus
Exosc7 - Exosome complex
exonuclease
RRP42; Non-catalytic component of the
RNA
exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular
RNA
processing
and degradation events. In the nucleus, the
RNA
exosome complex is involved in proper maturation of stable
RNA
species such as rRNA, snRNA and snoRNA, in the elimination of
RNA
processing
by-products and non-coding 'pervasive' transcripts, such as antisense
RNA
species and promoter-upstream transcripts (PROMPTs), and of mRNAs with
processing
defects, thereby limiting or excluding their export to the cy [...]
[a.k.a. 66446, ENSMUST00000215377.1, R-MMU-450513]
6)
Mus musculus
Dis3l - DIS3-like
exonuclease
1; Putative cytoplasm-specific catalytic component of the
RNA
exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular
RNA
processing
and degradation events. In the cytoplasm, the
RNA
exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in
RNA
surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA.
[a.k.a. Q8C0S1, NM_172519.3, Dis3l-206]
7)
Mus musculus
Mgme1 - Mitochondrial genome maintenance
exonuclease
1; Metal-dependent single-stranded DNA (ssDNA)
exonuclease
involved in mitochondrial genome maintenance. Has preference for 5'-3'
exonuclease
activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the
processing
of displaced DNA containing Okazaki fragments during
RNA
- primed DNA synthesis on the lagging strand or via
processing
of DNA flaps during long-patch base excision repair (By similarity). Specifi [...]
[a.k.a. BC063088, XM_006500302, 74528]
8)
Drosophila melanogaster
CG18809 - GH15549p; 3'-5'
exonuclease
activity; 5'-3'
exonuclease
activity. It is involved in the biological
process
described with:
RNA
phosphodiester bond hydrolysis, exonucleolytic; determination of adult lifespan.
[a.k.a. FBgn0042132, CG18809-PC, CG18809-PD]
9)
Drosophila melanogaster
Rexo5 -
RNA
exonuclease
5, isoform A; Nucleic acid binding; 3'-5'-exoribonuclease activity;
exonuclease
activity. It is involved in the biological
process
described with: snoRNA 3'-end
processing
; rRNA 3'-end
processing
.
[a.k.a. FBgn0286051, Rexo5-PA, Rexo5-PB]
10)
Caenorhabditis elegans
dis-3 - Probable exosome complex
exonuclease
RRP44; Putative catalytic component of the
RNA
exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular
RNA
processing
and degradation events. dis-3 has both 3'-5'
exonuclease
and endonuclease activities (By similarity).
[a.k.a. C04G2.6, Protein DIS3 homolog, WBGene00001001]
11)
Saccharomyces cerevisiae
REX3 -
RNA
exonuclease
; required for maturation of the
RNA
component of RNase MRP; functions redundantly with Rnh70p and Rex2p in
processing
of U5 snRNA and RNase P
RNA
; member of RNase D family of
exonucleases
; Belongs to the REXO1/REXO3 family.
[a.k.a. YLR107W, AAB67549.1, REXO3_YEAST]
12)
Saccharomyces cerevisiae
RAT1 - 5'-3' exoribonuclease 2; Nuclear 5' to 3' single-stranded
RNA
exonuclease
; involved in
RNA
metabolism, including rRNA and snoRNA
processing
, as well as poly (A+) dependent and independent mRNA transcription termination; required for cotranscriptional pre-rRNA cleavage; displaces Cdk1p from elongating transcripts, especially as RNAPII reaches the poly(A) site, negatively regulates phosphorylation of the CTD of RNAPII, and inhibits RNAPII transcriptional elongation; Belongs to the 5'-3'
exonuclease
family. XRN2/RAT1 subfamily.
[a.k.a. YOR048C, NM_001183467.1, S000005574]
13)
Saccharomyces cerevisiae
RRP17 - Ribosomal
RNA
-
processing
protein 17; Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions;
exonuclease
required for 5' end
processing
of pre-60S ribosomal
RNA
.
[a.k.a. YDR412W, NP_010700.3, YDR412W_mRNA]
14)
Saccharomyces cerevisiae
REX2 - Oligoribonuclease, mitochondrial; 3'-5'
RNA
exonuclease
; involved in 3'-end
processing
of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP
RNA
; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D
exonuclease
.
[a.k.a. YLR059C, NM_001181946.1, 3.1.-.-]
15)
Saccharomyces cerevisiae
USB1 - U6 snRNA phosphodiesterase; Putative poly(U)-specific 3'-to-5'
RNA
exonuclease
; involved in 3'-end
processing
of U6 snRNA removing uridines and generating a terminal 2′,3′ cyclic phosphate; essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants; homolog of S.pombe gene, mpn1 and human gene, hUSB1; mutations in hUSB1 are associated with a rare genodermatosis, poikiloderma with neutropenia (OMIM 604173); Belongs to the 2H phosphoesterase superfamily. USB1 family.
[a.k.a. YLR132C, YLR132C_mRNA, NM_001182019.1]
16)
Saccharomyces cerevisiae
DIS3 - Exosome core complex catalytic subunit; has both endonuclease and 3'-5'
exonuclease
activity; involved in 3'-5'
RNA
processing
and degradation in both the nucleus and the cytoplasm; role in degradation of tRNAs; similar to E. coli RNase R and to human DIS3, which partially complements dis3-81 heat sensitivity; mutations in Dis3p analogous to human mutations implicated in multiple myeloma impair exosome function; protein abundance increases under to DNA replication stress.
[a.k.a. YOL021C, S000005381, 4IFD]
17)
Saccharomyces cerevisiae
REX4 - Putative
RNA
exonuclease
; possibly involved in pre-rRNA
processing
and ribosome assembly.
[a.k.a. YOL080C, CAA99090.1, Q08237]
18)
Saccharomyces cerevisiae
NGL2 -
RNA
exonuclease
NGL2; Protein involved in 5.8S rRNA
processing
; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p; NGL2 has a paralog, NGL3, that arose from the whole genome duplication.
[a.k.a. YMR285C, 3.1.-.-, YMR285C_mRNA]
19)
Saccharomyces cerevisiae
RRP6 - Nuclear exosome
exonuclease
component; has 3'-5'
exonuclease
activity that is regulated by Lrp1p; involved in
RNA
processing
, maturation, surveillance, degradation, tethering, and export; role in sn/snoRNAs precursor degradation; forms a stable heterodimer with Lrp1p; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays reduced transcription elongation in the G-less-based.
[a.k.a. YOR001W, sce:YOR001W, UNC733]
20)
Saccharomyces cerevisiae
XRN1 - 5'-3' exoribonuclease 1; Evolutionarily-conserved 5'-3'
exonuclease
; component of cytoplasmic
processing
(P) bodies involved in mRNA decay; also enters the nucleus and positively regulates transcription initiation and elongation; plays a role in microtubule-mediated
processes
, filamentous growth, ribosomal
RNA
maturation, and telomere maintenance; activated by the scavenger decapping enzyme Dcs1p.
[a.k.a. YGL173C, CAA59180.1, 4932.YGL173C]
4585 matches
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